Comprehensive reform plays an important role in implementing the scientific outlook on development and realizing coordinated development of regional economy The article’s analysis shows that the reasons that the state supports the comprehensive reform as a key step in the policy system of open and development of the Binhai New Area are not only that the establishment of a new system of Binhai New Area is the inherent requirement of the open and development, but also that the implementation of policies and measures of economic, social, environment and resources planning and management depends on an effective system of protection mechanisms, which need to deepen comprehensive reform to achieve Because of the characteristics of exploration and innovation ,the reform shows the form of experimentUnderstanding the comprehensive reform should grasp the three areas such as reform,comprehensive match and the first to try to Comprehensive reform in the new period is an effective way to deepen the reform,and a strategic move to implement the scientific outlook on development Finally, this paper puts forward some policy recommendations on the establishment of a mechanism to propose the reform of the trial and to avoid possible negative impact