Gene editing is a novel complicated leading technology. Undoubtedly, it has significant positive effects if used safely and reasonably. However, this technology does not get mature enough. Up till now, there are no strict scientific assessment criteria but many unexpected risks about such technology. Under these conditions, using the technology rashly may change human genealogy, bringing some unpredictable disastrous consequences. Even gene editing technology gets mature in the furture, ethical reflections, regarding how to use the technology in reasonable ways, will still be needed. Moreover, these reflections will contribute to avoiding deviating from the correct path, getting fundamental ethical common senses. For sound development of gene editing technology, promoting its benefits and abolishing its harmfulness, our studies and practices on gene editing should follow multiple principles, including the humanistic principle, the principle of impartiality, the principle of publicity and transparency, the principle of informed consent, the principle of responsibility and so on.