The event of gene-edited baby has put forward a new topic of "what kind of man to be cultivated", and brought new reflection on "how to cultivate man" for the new era. According to the event of gene-edited baby, this paper aims to discuss the influence and impacts on the theory of human essence, the theory of alienation and the human development from the perspective of Marxist humanism, and to analyze the main problems existing in the current personnel training in combination with the phenomenon of He Jiankui. On the basis of problem-oriented, it is proposed that talent cultivation in the new era needs combination of emotion and ration, truth and kindness, heaven and man, and knowledge and practice, to prevent the risk of new generation's alienation, and to cultivate man who can really shoulder the mission of national rejuvenation, with native land emotion, friendliness and harmoniousness, obeying the rules and regulations.