In the era of big data, the internet has become an important tool for the public to participate in anti-corruption campaign. Internet public opinion about corruption cases is becoming more and more important in the work of combating corruption and building a clean government. However, this kind of online opinion is uncertain as it is prone to trigger derivative effect. Effective response to internet public opinion about corruption cases has become an important issue to be solved in combating corruption and building a clean government. The response mechanism of internet public opinion about corruption cases implemented by local governments provides new ways and methods for innovating public opinion monitoring mode, improving the efficiency of research, analysis and disposal, and realizing the active response to internet public opinion about corruption cases. The study concludes that the grid-based governance mechanism of internet public opinion about corruption cases is a set of mechanisms including grid-based monitoring technology platform and grid-based public opinion monitoring, early warning, studying and judging, and guiding and handling. The popularization and application of grid-based governance mechanism need to further change the public opinion response concept, optimize the information technology platform, and improve the corresponding system guarantee.