The disease narrative in ancient China has a long history. It has completed a transformation from the tradition of witch doctors to the tradition of witch who crafts the history. The former is the object described, and the latter is the form of description. During the evolution from disease narratives in classics and historical books to disease narratives in literary works, the meaning of disease itself has changed. It no longer only refers to human physical diseases, but also has begun to be used as a metaphor to refer to various factors which would cause damage to the country. In terms of the content, the disease narratives in ancient novels are distinguished from realistic styles and metaphorical styles. The two styles of writing correspond to different thematic expressions. One is as a representation of daily life, the other is a metaphor of the destiny of an individual, a family or even a country. It’s worth noting that the latter one includes moral metaphors and destiny metaphors at the individual level, and political metaphors at the national level. Moral metaphors about disease are mainly manifested in the two aspects of natural justice and humanity, and the concept of karma has become the dynamic mechanism for the lack of morality in the narrative of the novel to lead to physical disease. The loss of morality is the direct reason of physical illness, and the therapy morally can help heal the sick. As far as destiny metaphors are concerned, some masterpieces of Ming and Qing novels depict the specific manifestations of mental illness in great detail, which has highlighted and strengthened the tragic theme of works. As for political metaphors, novelists in the late Qing Dynasty often used diseases as a metaphor for the devastated old China’s situation at that time so as to criticize social reality and the drawbacks of traditional culture, and to propose therapies to heal the country. The above three types in disease narratives, their contents include the cause of disease, the method of curing disease, and the result of getting the disease. And the theme of the work is intertwined with the triple metaphors of "disease", "treatment" and "medicine". Finally, the profound cultural connotations of the disease narratives in ancient novels can be explained with the concepts of "the unity of nature and man" and "the cognateness of Medicine and Confucianism". The theory of "the unity of nature and man" holds that in the traditional concept, there is a close relationship between man and nature, and violation of natural laws will be the predisposing factor for disease. Only by obeying the will of Heaven can we be free from disease. From the perspective of the evolution of traditional Chinese scholar culture, the concept of "the cognateness of Medicine and Confucianism" reveals that the principles of governing a country and treating diseases are inherently connected. Splendid words which are crafted awakening stories, as great hearts that are intended to enlighten and save the country, they complement each other and achieve each other. Those beautiful models of disease narrative are the result of the confluence of the two. At last, the disease narratives in ancient novels make it clear to us that for thousands of years, the common idea of both doctors and Confucians is not only to heal people’s diseases, but also to heal the society and the country.