The construction of a high-quality regional economic pattern is not a simple superposition of several independent regional strategies, but requires efficient linkages between regional strategies. Taking cooperation among urban systems such as metropolitan areas and city agglomerations as breakthroughs can further magnify the spillover effect of major regional strategies, and promote the coordinated and integrated development of a wider range of spaces. In October 2021, the "Outline of the Plan for Ecological Protection and High-Quality Development in the Yellow River Basin" was officially issued, proposing to build the "Zheng(zhou)Luo(yang)Xi(an) High-quality Development Cooperation Belt". "ZhengLuoXi(JinShanYu) High-quality Development Cooperation Zone" analyzed in this paper is located in the Yellow River Basin, at the junction of Henan, Shaanxi, and Shanxi provinces, encompassing Zhengzhou Metropolitan Area, Luoyang Metropolitan Area, Xi'an Metropolitan Area and Yellow River Golden Triangle Demonstration Area, linking two national strategies of high-quality development in the central region and the Great Western Development, including the two key regional sections of the Zhongyuan Urban agglomeration and the Guanzhongpingyuan Urban agglomeration, are an important layout for linking major regional development strategies and improving China's high-quality regional economic structure in the new development stage. ZhengLuoXi has an area of 202,000 square kilometers, with a regional GDP of 5.82 trillion yuan in 2020 and a population of 90.79 million. ZhengLuoXi initially formed the spatial structure characteristics of "three cores and multiple fulcrums" and the overall network pattern of "main axis leading, network convection, and cross-grouping". As a key construction area under the national major regional strategy of the Yellow River Basin, ZhengLuoXi has a solid foundation for social and economic development, and its construction to become the "fifth growth pole" of China's high-quality development is full of unlimited potential. ZhengLuoXi has the natural foundation and comprehensive advantages of cooperative development due to the geographical proximity, personal affinity, cultural connection, resources similarity, and economic relatedness of brother cities. Its high-level construction is a response to the national strategy, a need for ecological protection, an inevitable tendency for regional linkage, a driving force for optimizing the overall spatial pattern of the country, and a historical trend for inheriting the culture and civilization of the Yellow River. The construction of ZhengLuoXi should abandon the simple "mixing" of several cities in the geographical sense, and instead pursue the deep "integration" in the sense of innovative cooperation, economic development, environmental protection, social connection, and cultural civilization. This article suggests that ZhengLuoXi should adhere to the strategic thinking of "high-quality development" and establish the core awareness of "high-efficiency cooperation", "high-level openness" and "high-quality life" should be promoted in concert to jointly cultivate it into a demonstration zone and leading zone for national regional coordinated development and high-quality cooperation. At the same time, we call on the ZhengLuoXi high-quality development cooperation belt to become the second largest national strategy in the Yellow River Basin, and coordinate with the overall strategy to protect the ecological environment, and to build a strong fulcrum for the high-quality development of the Yellow River Basin and an important growth pole for China's economic development.