According to the 20th CPC National Congress Report, we will promote coordinated development among regions and thoroughly implement the strategy of coordinated development among regions, major regional strategies, the strategy of functional zones, and the strategy of a new type of urbanization. Although the development of the interprovincial borderline area on the geographical and administrative edge is an important bearing place of the above national strategies, it has always been a prominent weak link in the regional coordinated development of China due to various reasons. How to focus on the difficult and painful points in the development of border areas and promote small-scale, cross-regional and relatively accurate cooperation between provincial border areas is an important breakthrough to implement national strategies and promote regional coordinated development to a higher quality and deeper level. In this paper, the boundary area of three provinces of Hubei, Henan and Shanxi, which is located in the superposition area of several national strategic plans, the optimization area of regional coordinated development layout, the ecological resources agglomeration area of South-to-North water transfer, and the Qinba Mountain poverty alleviation model area, is selected as the unique research object. Based on the border area in economy, industry, population, transportation, innovation of property and relational data, this paper analyzes the temporal and spatial development characteristics of the Hubei-Henan-Shanxi border area from the perspectives of regional internal development and regional external connection as well as the spatial scale of cities and districts. Results show: EYuShan border area economic development has obviously inadequate and unbalanced characteristics, although the county economic development level between the spatial agglomeration rising, the spatial agglomeration is still at a lower level, and mainly reflected in the agglomeration characteristics in the province, the administrative border to border area development block effect is obvious; In the border area, the industry correlation is weak and the industry homogenization is serious. The boundary area and adjacent area formed the "depression" of population outflow and showed obvious characteristics of population contraction. The transportation infrastructure is weak and the inter-regional transportation network accessibility is low. Weak cooperation in science, technology and innovation and insufficient impetus don’t meet to innovative development; The form of regional cooperation is single, and the impetus of regional cooperation is insufficient. To solve the above problems, from the regional cooperation model, traffic infrastructure construction, ecological environment development and opening to the outside world, this article further puts forward EYuShan border regional coordinated development path and measures, explore the administrative subordination relations not change under the prerequisite of the implementation to promote the development of regional cooperation between the EYuShan path. It is proposed that the spatial structure of the borderline area should be optimized by building a new model of "four-height" development and constructing a demonstration area of interprovincial adjacent and integration in the central and western regions, so as to provide experience and reference for promoting inter-regional cooperation of the interprovincial borderline area.