Since 2025, the accelerated implementation of U.S. tariff increases on Chinese goods has transcended traditional trade frictions, evolving into a systematic suppression tool with multi-dimensional coordination across economic, strategic, political, and technological domains. Economically, it aims to balance trade deficits and enforce protectionism; strategically, to restructure global supply chains and reduce dependence on China; politically, to divert domestic tensions and engage in geopolitical rivalry; and technologically, to stifle China’s innovation leapfrogging and maintain generational advantages. These high tariffs impose systemic risks on China’s private economy, including supply chain strain (persistent cost escalation), export contraction (compressed traditional markets), technological containment (fractured innovation ecosystems), and talent drain (restricted high-end intellectual inflows). In April 2025, General Secretary Xi Jinping’s inaugural proposal of the Asia Security Model at the Central Conference on Peripheral Work marked China’s strategic shift from passive defense to proactive rule-shaping in regional governance, offering a new paradigm for private sector resilience. This study proposes a five-dimensional strategic framework: reform and opening-up, government-enterprise collaboration, market expansion, risk prevention, and innovation-driven development, to navigate U.S. tariff pressures. Key measures include: strengthening domestic circulation as the cornerstone while promoting dual domestic-international cycles; enhancing institutional safeguards and policy support for private enterprises; deepening multilateral cooperation under the Belt and Road Initiative; building trade early-warning systems and legal protections; advancing sci-tech system reforms and talent ecosystem optimization. This transformation not only provides practical guidance for Chinese enterprises to counter U.S. trade tactics but also offers a China solution for emerging economies to break the core-periphery dependency through institutional innovation. By integrating reforms into global governance restructuring, China aims to convert tariff crises into historic opportunities for rule-making—a pragmatic response to unilateral hegemony and a strategic commitment to advancing a shared future for humanity.