The strategic alliance of industryuniversityresearch has much influence on the development of industrial clusters, for it is an economic phenomena which originated from them. The paper starts with the analysis of the characteristics of the strategic alliance of industryuniversityresearch institutions which based industrial clusters,then,it explores the current three forms of strategic alliances and its impact on the role of industrial clusters and puts forward the cooperative mechanism of the strategic alliance of industryuniversityresearch which consists of the work division mechanism, coordination mechanism, communication mechanism, culture integration mechanism, talents exchange mechanism and interests distribution mechanism from the angle of giving full play to the advantages of the strategic alliance itself and improving the competitive strength of the whole industry clusters.