The college students' ability of innovation of science and technology is the future of the country foundation of innovative ability.It needs to build a scientific and lasting effect mechanism to strengthen cultivating students' innovative ability. On the basis of the successful experience of the study of Harvard University students science and technology innovation ability cultivation mechanism,this papper analyzes the baisic situation of China's college students' science and technology innovation ability cultivating mechanism,combines with the actual situation of China and suggests we should draw lessons from the successful experience of Harvard University, innovates the concept of education,deepens the reform of education and teaching, strengthens the construction of teachers' team,attaches importance to science and technology innovation practice,cultivates students' creative personality and constructs the campus culture of innovation in order to further improve students' science and technology innovation ability cultivation mechanism.