There is a certain difference and close connection between the ideological and political education in colleges and universities in the era of big data and the traditional one. In the era of big data, to grasp the relationship between "changes" and "invariance", the ideological and political education in colleges and universities should realize its goals through the change of ideological and political education concept, educational attainment, education method and main structure on the premise of insisting on guiding ideology, fundamental task, fundamental purpose and main principle, combining with the new situation in the era of big data. In the era of big data, the "change" and "invariance" of ideological and political education in colleges and universities are a dialectical unity. "Change" is the practical wisdom of "invariance", and "invariance" is the essence of "change." "Change" and "invariance" are dialectically unified in the development of ideological and political education in colleges and universities.