Facing the tidal wave of global digitalization, enterprises are facing more and more management challenges in the process of digital transformation. The end of management is not that management is disappearing, but that management around controlling labor will be replaced. Management regeneration refers to the paradigm shift of management from controlling labor force to liberating labor force. Tracing back the history of management, based on the 25-years cycle evolution theory, this paper proposes that under the promotion of digital technology, 2035 will be the key period of the end of management and regeneration. By analyzing the management impact brought by digital technology, the direction of management regeneration facing 2035 lies in the paradigm shift of management, that is organizational culture with "liberating labor force" as the core being integrated with digital technology. Thus, the only way out for China’s local management innovation lies in the digital management with Chinese cultural characteristics.