Finite element software was used to simulate the internal force and deformation of high-rise pile cap-soil-structure under the wave and earthquake action. Meanwhile, wave force was calculated by using Morison equation, and the mechanical behavior of structure was simulated by inputing horizontal El-Centro wave. Then, the initial state and the state of the largest positive and negative acceleration were selected to study the structure according to the time history curve, and the displacement, bending moment, shear and axial force changes of pile foundation under wave and earthquake action were discussed, which was compared and analyzed with the structural response under the action of earthquakes solely. The result shows that the moment of front row of piles is biggest, and the force of pile bolck is the most dangerous; the axial force of the corner piles is the largest, and one of the center piles is the smallest under the action of wave and earthquake. When the wave forces and seismic forces are in the same direction, the displacement, moment, and shear force of pile bolck will be increased, on the contrary, the displacement, moment, and shear force of pile bolck will be decreased.