Soft clay is stabilized by desulphurization gypsum and steel slag-slag blended cementitious materials (GSC), which can not only reuse industrial waste and decrease second pollution, but also can conserve mineral resources and protect natural ecology. The variation of unconfined compressive strength of the clay improved by GSC with different mixing ratios and water-GSC ratio and ages was studied through the laboratory experiments. The long-term strength of stabilized soil is predicted with GSC by quasi-water-GSC ratio. The results show that the more the mixing ratios is, the better the stabilized effect of soft soil is. With increase of curing period, the strength increasing of GSC-soil is consistent with cement-soil, and it has lower strength in the early stage. When mixing ratios of GSC is more than those of cement by 3%, if the water-GSC ratio is less than those of cement, it has the higher strength than cement-soil, after 28 days. The results show that GSC stabilized soil is feasible and it can meet the demand of cure strength.