The climate has a great impact on highway bridge rubber bearings than on building rubber bearings. In order to study the change of the mechanical properties during the life of the plain chloroprene rubber bearings of highway bridge under freeze-thaw cycle condition, the plain chloroprene rubber bearings were processed 25, 50, 75, 100 times by freeze-thaw cycle in the standard freeze-thaw chamber, then the axial compression tests were carried. The changes of the performance indicators in the bearing capacity , the ultimate compressive strength, vertical stiffness, elastic modulus under different freeze-thaw cycles were analyzed comparatively. The results show that the plain chloroprene rubber bearings are more prone to brittle failure after the freeze-thaw cycle, and the failure phenomena of steel plate exposing or cracks is more serious than the phenomena of the standard specimen. With the increase of the number of freeze-thaw cycle, the ultimate bearing capacity, ultimate compressive strength and compressive elastic modulus of the plain chloroprene rubber bearings decrease. The attenuation formula and decay curve in 50 years of ultimate compressive strength and elastic modulus of compression are analyzed by least square method, the trends of change are both in line with the exponential function. The mechanical properties of plain chloroprene rubber bearings of highway bridge significantly decreased under freeze-thaw cycle condition. therefore, the temperature ranges of plain chloroprene rubber bearings of highway bridge should be strictly controlled, and some suggestions, such as increasing its minimum applicable temperature, usng the natural rubber bearings as much as possible in cold regions, have been given.