In order to study the influence of slope on the vertical bearing characteristics of pile foundation, combined with model test and numerical simulation method, multiple groups of slope conditions and horizontal ground condition were designed to study the vertical bearing characteristics of single pile. The vertical bearing capacity, axial force, side friction and load transfer mechanisms during load-bearing of pile was compared and analyzed in unilateral slope and continuous slope with the same pile length. The results show that:1.Under the same slope condition, the single-pile bearing capacity of unilateral slope is less than that of continuous slope, and the vertical ultimate bearing capacity of pile decreases with the increase of slope gradient, and the slope influence degree increases non-linearly; 2.The slope type mainly affects the peak value of the pile side resistance, and the pile tip resistance is close when the pile side resistance peaks. 3.In the slope, there is a difference in the stress distribution between the front and back of the pile body. The vertical stress and shear stress at the front of the pile body are larger than that at the position back of the pile body, but the difference in shear stress only exists in the area around 0~4 times the pile diameter.