This paper takes the antimony mine wastes from Xikuangshan (XKS) Antimony Mine in Lengshuijiang City, Hunan Province as the research object, and studies the leaching and releasing regularity of heavy metals from antimony mine wastes comprehensively and systematically. The content of heavy metals in antimony mine wastes and leaching solution was determined through the digestion test and semi-dynamic leaching test, and the release regularity of Sb, As and Hg in antimony mine wastes leaching solution was analyzed. The results show that the concentration of heavy metals in antimony smelting slags is relatively high. The concentration of As in all the three kinds of antimony mine wastes exceeds the risk screening value of “Standard for Risk Control of Soil Pollution in Agricultural Land of Soil Environmental Quality” ; the concentration of Sb, As and Hg in antimony mine wastes exceeds the standard background value of soil in Hunan Province. The leaching concentration of Sb, As and Hg in antimony smelting slags reached the maximum in 2-3 days of leaching, and the leaching concentration of Sb, As and Hg in antimony ore waste rocks and antimony ore tailings reached the maximum on the first day of leaching, the antimony mine wastes from which the amount of heavy metals can be precipitated from the most to the least is in the following order: Antimony smelting slags > antimony ore tailings > antimony ore wastes. There is a quadratic function relationship between the cumulative leaching amount of heavy metals from antimony mine wastes and the cumulative leaching amount of simulated acid rain. The experimental results will provide some theoretical support for the prevention and control of soil-groundwater pollution by antimony mine wastes.