NF-HF and NF-HS nanofiltration membranes were employed to separate secondary reverse osmosis concentrate from coal-chemical wastewater treatment plant. The separation efficiency of Cl^- and SO4^2-, rejection efficiency of scaling ions and anti-fouling property of the two types membrane were investigated. Space Tube reverse osmosis (STRO) was used to concentrate permeate of NF-HF. The results show that NF-HF membrane has better Cl^- and SO4^2- separation efficiency and scaling ions rejection efficiency than NF-HS membrane, whose rejection efficiency are 3.38~16.03% for Cl^-, 91.18~97.16% for SO4^2-, 90% for Ca²⁺, 80% for Mg²⁺ and 40% for SiO2, respectively. Moreover, NF-HF shows excellent antifouling property. The operating pressure rises slowly from 32 bar to 45 bar after running 336 h and the membrane flux is recovery completely after alkaline washing. STRO shows good concentrating effect and COD removal efficiency but poor anti-fouling performance. Therefore, the separation and concentration coal chemical wastewater with of NF-HF-DTRO (Disc high-pressure reverse osmosis) combination process is practicable.