A shaking table test is carried out for the bedding rock slope with building pile foundation. The seismic dynamic response of the system is studied mainly include prestressed anchor cable, the building pile foundation and the acceleration response of the slope. The results indicate that the strain of the anchor cable changes with the seismic wave, and the strain of the anchor cable reaches the maximum when the seismic wave reaches the peak, the upper cable force is larger than the lower. When the seismic amplitude increases, the upper anchor cable slips, and loses anchor effect. The maximum strain of building pile foundation is located at a certain depth below the sliding surface, and the stress of building pile foundation far away from the slope is greater than the one near the slope. The peak accelerations of slope top increase linearly with the seismic amplitude, but under the condition of WenChuan-WoLong wave (0.55g) amplitude and Sin wave (0.4g) amplitude, there is a decreasing tendency among the peak acceleration at each point. With the increase of seismic amplitude, the peak acceleration amplification coefficient of each point under Wenchuan and Sin earthquake does not change monotonously, but decreases first, and then increases.