In order to improve the defects of vacuum preloading method, a method of PHD-PVD vacuum preloading combined with electroosmosis to treat engineering waste slurry was proposed. Through six groups of large-scale indoor model tests, the drainage, current intensity and settlement value during the consolidation process of engineering waste slurry are monitored and the soil reinforcement effect after the test is evaluated. The best potential gradient is determined and the effects of electroosmosis treatment and intermittent disconnection of vacuum pump and power supply on PHD-PVD vacuum preloading are analyzed. The test results show that the combination of electroosmosis method can effectively improve the drainage efficiency of PHD-PVD vacuum preloading method in the later stage, and the far end soil has a high degree of consolidation; The intermittent disconnection alleviates the blockage near the drainage board to a certain extent and improves the drainage effect. By analyzing the microstructure of the soil after the test with the help of mercury intrusion test (MIP), it is found that the pore distribution in the treated engineering waste slurry soil is a single peak distribution. The peak pore diameter of the engineering waste slurry soil treated by intermittent disconnection PHD-PVD vacuum preloading combined with electroosmosis method is smaller, and the soil microstructure is more compact.