The anodic oxidation method has strong oxidation capacity and low secondary pollution, making it highly promising in the treatment of landfill leachate. This study constructed a flow-by and flow-through reactors using Ti4O7 electrodes and systematically investigated their performance in the deep treatment of leachate effluent. The results showed that in the Flow-by mode, with a current density of 60 mA/cm2, pH of 8, and Cl- concentration of 200 mg/L, the operation for 240 minutes resulted in a COD removal rate of 77.47%, significantly higher than that of the Flow-through mode (60.56%). The Flow-by mode can also more effectively alter the composition of DOM, with higher pre-treatment efficiency, and can mineralize and remove most of the dissolved organic matter. In conclusion, the Ti4O7 anode reactor has significant advantages in treating landfill leachate.