The reservoir sandstone is the sedimentary rock with many cemented sand particles. The different physical property of the reservoir even in the same area results in different mechanical response and sand production of the sandstone. Taking two types of the reservoir sandstones as research subjects, a numerical model based on 3-Dimensional Particle-based Distinct Element (PFC3D) under cylindrical coordinate system was used to simulate the micro-micro response of the sandstone considering the given confining pressure and the oil flow rate. Meanwhile, the sanding initiation and the process of the development were analyzed. The macro stress indicated that the reservoir sandstones with weaker cemented sand particles and less percent of the cemented materials would yield and fail more easily, the sand production was initiated more easily as well. Meanwhile, the stress of the parallel bonds indicated that the reservoir sandstones with granule and less cemented materials dislodged from the sandstone more easily, and the force on the particle contact was larger and the sandstone failure was more serious.Hence, the probability of the dislodged particles flowing into the wellbore was also much more. In addition, the particle displacement and rotation indicated that the physical property of the sandstone played a significant influence on the mechanical response and the sand production, the results also agreed with the above results. Therefore, the sand mechanical response and sand production of reservoir sandstone are both different due to different physical property of the reservoir. As a result, the reliable measures of the sand prediction and sand control will be adopted based on the reservoir physical property and conditions.