The composite photocatalysts were made by using solid dispersion method with nano-TiO2 loaded on hydrophobic or hydrophilic zeolite and zeolite with different pore diameters. The removal and mineralization efficiency of oxytetracycline (OTC) in aqueous solution were investigated under the irradiation of 32 W UV lamps by composite photocatalysts loaded with different ratios of nano-TiO2. The results showed that UV/10%TZ2 (hydrophilic zeolite) achieved a better removal efficiency of OTC than UV/40%TZ1 (hydrophobic zeolite) while UV/15%T5A (hydrophilic zeolite with a pore diameter of 0.5 nm) achieved a better removal efficiency of OTC than UV/10%T13X (hydrophilic zeolite with a pore diameter of 1 nm). That is to certify that the hydrophilic zeolite and zeolite with small pore diameters loaded with nano-TiO2 could achieve better removal effects for OTC in aqueous solution. The OTC that adsorbed on the inside surface of 13X cannot be degraded due to the out range of hydroxyl radicals attack.