The explicit dynamic FEM-based code AUTODYN was used to study the effect and law of barrier holes on blast-induced stress wave propagation and attenuation, as well as the dynamic responses of adjacent underground opening and ground. First of all, compared with the results of blasting model test, the effectiveness and accuracy of AUTODYN to simulate the process of underground opening explosion and stress wave propagation are verified. Then, the effects of different barrier hole parameters on peak particle velocity (PPV) of the adjacent chamber and ground, and the vibration-isolation rates of measuring points before and after barrier hole screen were analyzed through the numerical simulation method， and the pattem of varying barrier hole parameters on vibration reduction effect is revealed. The simulated results indicated that barrier hole diameter, hole spacing, the distance between hole and explosion center, and hole row have effects on PPVs of adjacent underground opening and ground and the vibration-isolation rates of measuring points before and after barrier hole screen. With increasing barrier hole diameter and barrier hole row, or decreasing barrier hole spacing and distance between barrier hole and explosion center, PPVs of the adjacent underground opening and ground show a decreasing trend and vibration-isolation rates of measuring points before and after barrier hole screen show a great increasing trend, that is, the vibration reduction effect of barrier hole is enhanced. In addition, with change of barrier hole parameters, the vibration-isolation rates of the measuring points before and after barrier hole and the measuring points before and after rock mass between barrier holes show significant differences. The former is obviously larger than the latter, and the difference between the two increases first and then decreases with increase of hole diameter, and decreases rapidly with increase of the distance between hole and explosion center. But it doesn't change significantly with the increase of barrier hole row. The change of barrier hole spacing could affect the relative position of the measuring point and the barrier hole, thus determining the vibration-isolation rate of the measuring point.