In this paper, the advanced construction technology and site management applied in bid construction part B of Yangtze River bridge in Jiangyin was presented in detail. This bridge is the largest span bridge in China, where the advanced technology applied is: 3-d coordinate control surveying in bridge tower, small powder for artificial pile, over-form and climb form in construction of tower column, temperature control for casting mass concrete. It is of great value for reference to large bridge building.