In this paper, based on the discussion of orthogonal decomposition method for the buckling mode of unsymmetrical structure, taking the variable-section beam-column as an example, a simple and direct method of the second order analysis is presented. In the new method, the conception of enlargement coefficient brought forward by Timoshenko is developed. To begin with the curvature of the variable-section beam-column, the linear equations are set up. With their solution, a group of orthogonal buckling mode can be obtained. The primary deflection can be decomposed to a group of homomorphic deflection similar to buckling mode. Then, the group of deflection is multiplied by corresponding enlargement coefficient and plus the result, finally, the second-order total deflection can be obtained.