Autogenous relative humidity (ARH) reduction and autogenous shrinkage (AS) due to self-desiccation are common phenomena in high performance or high-strength concrete, which are the main reasons resulting in cracking of concrete at early ages. In this paper, the effects of the ratio of water to cementitious material (w/cm), paste volume content and the combined addition of silica fume (SF) and ground blast furnace slag (GBFS) on ARH change and AS of concrete due to self-desiccation were studied, and their relationship was discussed. The results indicate that the w/cm is a main factor affecting ARH change and AS of concrete. With the reduction of w/cm, ARH change and AS of concrete increases. The combined addition of SF and GBFS also augments these properties at later ages. There is significant linear correlation between ARH change and AS of concrete with different w/cm, paste volume content and the combined addition of SF and GBFS.