For prestressed frames, the axial compression ratio will affect not only the ductility of structures but also the structural internal force.Based on the computer-calculation for four groups of 24 prestressed frames combined with the references, in this paper, the effects of axial compression ratio on the prestressed frames are studied and discussed through three aspects: the second-order effect, the axial deformation of frame-columns and the comparison with ordinary concrete frames.The study results show that the effects of axial compression ratio on the prestressed frames and the ordinary concrete frames are basically consistent, but there are some self-born characteristics.As a whole, the effect of axial compression ratio on the prestressed frames is more notable than that on the ordinary concrete frames, but under common situation the effect is small.