By review of region study in recent development of history science, geography and Sciences of Human Settlements, this paper points out that material collecting without interrelated analyzing as well as focusing on main question and assumption without enough argumentation are main problems in this field now. The method renovation & combination with related subjects are discussed, this paper concludes that strengthen interdisciplinary study with Geography is a key issue in the future development of region study in Sciences of Human Settlements and possible approach to "technical development' and "humanity concern'.