In this paper, a study is carried out on large-span prestressed concrete structure system in residence analyzed by specially - shape column equivalent frame model. Applying fiber model column-beam element and shell element, a large amount of comparative analyses about large-span prestressd concrete structure under horizontal and vertical load is carried out. The parameter of the equivalent frame is confirmed based on comparison with the result of the man-sized structural experiment. It is proved that the equivalent frame model has high efficiency and precision especially for nonlinear analysis.