Customer Relationship Managment is a kind of new-type management mechanisms that aims at improving the relation between the enterprise and customer and increasing the customer's loyalty and satisfaction.This thesis begins with the connotation of CRM and explains the structure of CRM system.Then the thesis lays particular emphasis on describing CRM application in real estate enterprises under the environment of e-commerce in terms of enterprise's key competitiveness.It is pointed out that a comprehensive appraisal from multiple angles should be carried out to evaluate the CRM system.