The large-span structure requires wind vibration analysis when computing the wind load;however,the formula in current code on wind vibration coefficient can hardly be applied in large-span structure,making its computation difficult and troublesome.This paper makes wind vibration analysis on the large-span curtain wall combined with certain engineering background in the methods of both time domain and frequency domain,and then the derived results are compared.The analytical results demonstrate identical distribution and contiguous numerical value of wind vibration coefficient concluded from the two varied methods;furthermore,even if the method in time domain is higher in computational complexity,more data on the response of structure under wind can be obtained,which provides reference for the theoretical analysis and engineering design.