The aims at optimization of structure with damper braces is studied in this paper. The sum of damping coefficient of all damper braces is considered as a goal function, and the storey displacements are considered as constraint conditions. The program,which introduces the non-proportional damp matrix, based on genetic algorithm and time history is used to analyze the optimization of a damper braced frame. The results are reasonable and show that the genetic algorithm is an efficient method to optimize the damper braced structure.