The secondary moment of prestressed concrete frame is different from that of continuous beam. In this paper,the principle and calculation method of equivalent load secondary moment and axial secondary moment are discussed,and the infection of secondary moment in moment modulation is analyzed,together with the suggestions of moment modulation for prestressed concrete frame with adopting the total control. The suggestions would be able to distinguish the advantageous and disadvantageous effect of secondary moment. Some helpful advises for moment modulation design are given in this paper.