Thermal stress is one of the important influence factors of crack and deformation for large-span bridge structures. Grounded on Shibanpo Yangtze River double line bridge and universal finite element program MIDAS-Civil with referring to specifications of China and British BS5400, above all, it is for this Bridge that the stress and deformation influence is studied by setting section temperature difference and system temperature change, afterwards, the effect on the newborn bridge is discussed by combining impact of the section temperature difference and the system-calefaction linearly , and then, the effect is compared with the impact brought by moving load. The results will have a certain extent value for the design of ShiBanpo double line bridge and other similar bridges.