Intelligent materials, control devices and intelligent control algorithm research and development in recent years have opened a new world for seismic resistance and disaster reduction in civil engineering. We designed and fabricated a new piezoelectric friction damper. In our research, we regarded the piezoelectric friction damper as the control device. We proposed a fuzzy control algorithm for reducing nonlinear seismic response of a 3story benchmark building and established the interactive relationships between structural responses and fuzzifier factors, defuzzifier factor. A numerical simulation is carried out to analyze the nonlinear seismic responses of the controlled 3story benchmark building. The simulation results are compared to those of other control strategies. The results show that the fuzzy control can reduce the nonlinear seismic response of 3story benchmark building and minimize the structural damage caused by strong earthquakes.