Excessive creep camber of prestressed concrete bridge would result in risk on the traffic safety in highspeed railway. To control creep camber of presstressed concrete bridge, a new twiceprestressed technology was proposed to presstressed concrete beam. Four twiceprestressed simply supported box girders with different prestressed degrees were designed as an example. Its section stress, strength and crack resistance in different construction stages were analyzed. Compared the creep camber between conventional prestressed simply supported concrete beam and twiceprestressed simply supported composite beam with the same prestressed steels, it was shown that twiceprestressed composite beam has a smaller stress gradient. And the creep camber decreased approximately 40% to 60% with building height reduction, as well as some 10% energy saving and some amount of concrete.