According to characteristics of largespan structures, a methodology was proposed to analyse the equivalent static wind load for multiple targets of China’s National Stadium. The general principles were, taking dominating eigenmodes and dominating vibration modes as basic vectors to express equivalent static wind load for multiple targets; and then obtaining optimization coefficient with least square approximation method; thus, obtaining the equivalent static wind load for multiple targets. Upon the case study, it was found that background response was much more than resonant response for all of the wind directions with most unfavorable at 0 degree and 270 degree directions. And structural response of all nodes and all supports under a single equivalent static wind distribution were in good agreement with peak values under actual dynamic wind loads at the same time.