In order to improve utilization of cold and heat source from river, turbulence theory and entropy generation theory were adopted to analyze the effect of fouling on convective heat transfer performance in small diameter tube of constant wall temperature.It is found that the entropy generation caused by conduction of fouling plays a more important role in total entropy generation of heat transfer process through a duct than that in cveast rate of caused by temperature difference.The entropy generation caused by viscous flow is more than the entropy generation caused by temperature difference in flow with bigger Reynolds and small radius.The increase rate of entropy generation monotonically increase with Reynolds and the generation process of fouling resistance.Thereafter, the effect of fouling resistance on the heat transfer performance of water source heat pump heat exchanger should be paid more attention, when river water are used as the cold and heat source of heat pump.