The fatigue resistance of Gussasphalt mixture was analyzed with energy method after fourpoint flexural fatigue test under multiple strain levels. Through the fatigue test under multiple strain levels, the linear relationship was obtained between fatigue life and cumulative dissipated energy in loglog plot. And the equation for fatigue life prediction under different strain levels was also regressed. Besides, the relation between fatigue damage and dissipated energy of Gussasphalt mixture was analyzed with Maxwell model. And with the conceptions of hysteresis loop and phase angle, it is found that the mixture with bigger phase angle has better fatigue resistance.