The static load test and the finite element analysis of the multi-tower cable-stayed bridge with tie-down cables are carried out. The test and analysis model of the bridge is created by referencing to the actual structure of a Changjiang River bridge. The static mechanical behaviors of such bridge with tie-down cables and the normal multi-tower cable-stayed bridge are comparatively analyzed by the static load test and the finite element analysis. It is shown that the structural system of the cable-stayed bridge with tie-down cables can effectively improve the structural rigidity and reduce the bending moment of the main beams, pylons and piers. According to the results, the best scheme about the location and number of tie-down cables is proposed.