Based on the damage assessment and strengthening scheme of the full-scale model which is the three-floor frame-supported reinforced concrete masonry short-leg shear wall structure, the strengthened model is tested using the substructure pseudo-dynamic testing method. The applicability of the proposed strengthening technique for the building damaged by earthquake is discussed. Thus, the seismic performance of the strengthened model is proposed to seek the strengthening technique for the structure damaged by earthquake, and it provides important reference for the post-disaster reconstruction after Wenchuan earthquake.