The uniaxial load tests were conducted to investigate the material behavior of CFRP sheets. The results show that the probability distribution of CFRP tensile strength can be described by the three-parameter Weibull distribution. The design formulae for determining flexural capacity of reinforced concrete strengthened with CFRP sheet are proposed. The Monte Carlo procedure was applied to simulate the flexural capacity of reinforced concrete strengthened with CFRP sheet. By using the JC method, the reliability index was calculated based on the statistics of flexural capacity and load effect. After the analysis of the effect of the partial factor of CFRP sheet on the reliability index, the results reveal that the reliability index of all design points are the most close to target reliability index overall when the partial factor of CFRP sheet is 1.25，and in this condition the reliability index of three flexural failure modes achieve the target reliability index respectively. Therefore, the partial factor is suggested to be 1.25, which meets the requirement of reliability design.