Pseudo-static tests of three one-storey spatial RC frame-shear wall structures with floor slabs were conducted to investigate their failure modes and hysteretic behaviors. The test results were compared with those of pushover analysis. It is shown that: 1) damage of the frame beams occurs later and is less than that of the shear wall and the frame columns; 2) damage of the floor slabs under lateral loading is significant in regions close to the shear wall, and tensile stresses of slabs' steel bars in these regions are much larger; 3) in comparison with the case that the floor slabs are neglected, the maximum lateral load that a frame-shear wall structure can bear is larger in the case that the floor slabs are taken into account, and the contribution ratio of the shear wall also increases; 4) shear forces carried by the frame columns with identical cross sections and reinforcement details but located at different positions are close to each other on the whole.