Considering the damage of concrete mechanical properties and bonding behavior between the steel bar and concrete after the freezing and thawing function in the numerical simulation, the nonlinear analysis on flexural performance of reinforced concrete beam which experiences different salt-frost cycles is conducted, and the evolution law of resistance performance of reinforced concrete beam is studied. It is shown that, in the salt-frost environment, the decrease of concrete mechanical properties is the main reason that causes the degeneration of RC beam on flexural performance, while the reduction of bonding property has an unobvious effect on the beam resistance performance. When the salt-frost cycles reach a certain level, the beam failure pattern would change from the under-reinforced failure to over-reinforced failure. The freeze-thaw damage of bonding property in the beam-ends anchorage zone has a certain effect on the beam resistance behavior, especially for the more serious freeze-thaw degree, the resistance performance of the beam reduces about 4% than the perfect anchor beam.