On the construction of large-span prestressed box beam Cantilever, the parameter frequent changes in concrete modulus E, coefficient of thermal expansion α.In a certain temperature case, the change of concrete parameters will cause the changes on internal stress and strain of the bridge and the difference of the changes will affect the bridge safety. Accordingly,based on a bridge cross-section of a temperature field and combined with the actual bridge construction, give concrete Cantilever bridge parameters change, calculated and analyzed the sphere of influence of parameters on the stress and strain fields of bridge, asked the law of sensitivity on stress changes. Summarize the sensitivity factors of temperature stress which is used to improve bridge safety.