In the sinking process of large-scale caisson, the distribution of the shaft friction and the end resistance is the main controlling factor of the sinking feasibility, but the research based on large-diameter piles and small or medium-scale caissons are no longer applicable. With the real-time monitoring data of the south anchorage caisson sinking process of Yangtze River Highway Bridge in Ma An Shan, this paper analyses the underlying principles and the mechanical characteristics in the sinking process of the large-scale caisson foundation, Verify the applicability of different formulas of the foundation ultimate bearing capacity in the of the caisson; Contrast sink to different depths , the value and the distribution rules of the shaft friction and the end resistance, this paper also modifies the formulas and distribution characteristics of the shaft friction proposed by current specifications, and the conclusions are suitable for reference of similar scale projects.