High-strength concrete has been widely used in civil structures for advantages of higher-strength, earlier curing strength and smaller deformation in applications. However, relatively weak ductility in structures in seismic zones prevented it from further application. The ductility of the structure can be improved by reinforcing reasonably rebars in correct details. A high strength RC frame model with twelve floors and two bays is numerically analyzed by using DRAIN-2DX program. It was shown that this worked fairly well in simulation of the process of structural damage and energy dissipation capacity. It also showed that this kind of frame structure has good ductility and dissipation capacity as well as great seismic performance. The proposed method can be applied in high-strength concrete structures in seismic zone.