Intermittent operation can affect the heat exchange performance of the vertical ground source heat pump system, thereby affecting life cycle cost (LCC) of the ground source heat pump system. The simulation analysis on the hourly load of an office building is implemented by using the DeST software.The heat exchange model of vertical ground heat exchanger pipe-group and energy consumption model of per part of heat pump system are established. Through the comparison between calculation results of continuous operation for 15 years and calculation results of intermittent operation 15 years of the heat pump system, it can be concluded that the LCC value of intermittent operation decreased by 13.45%,relative to the LCC value of continuous operation, and the average energy saving rate of intermittent operation mode is 17.20% in the entire life cycle. Intermittent operation mode can effectively improve energy efficiency of the ground source heat pump system and reduce the LCC value.