Based on OpenSEES platform, elastic-plastic structural model of long-span bridge with high piers is established. This paper utilizes time-history analysis method to analyze seismic responses of bridge under consistent or multi-support seismic excitation. Seismic performances and failure process for bridge with high piers are studied. Analysis results show that characteristics of seismic excitation and the way of excitation input have some effect on failure sequence and the occurrence or location of plastic hinge for bridge piers. The failure mode for high piers assumes bending failure, and the failure for top of pier is frequently prior to that of pier bottom, which should be paid enough attention.